R01NS39163/NS/NINDS NIH HHS/United States, R24HD39621/HD/NICHD NIH HHS/United States, NCI CPTC Antibody Characterization Program. Translational Research in Traumatic Brain Injury. Whyte J, Vaccaro M, Grieb-Neff P, Hart T, Polansky M, Coslett HB. 03 Pharmacological interventions for agitation in patients with traumatic brain injury: protocol for a … Objective: To assess the effects of multidisciplinary rehabilitation interventions and use of bromocriptine on outcome in patients with traumatic brain injury-vegetative … Am J Phys Med Rehabil 2008 ; 87:85–99 Crossref , Medline , Google Scholar 32. 05, No. Conclusion: Trials. 2014 Feb 13;15:54. doi: 10.1186/1745-6215-15-54. In 41.2% of cases (7/17), Glasgow outcome score (GOS) was improved to 4/5 in 90 days. Bromocriptine improves neurological sequelae of traumatic brain injury as well as the overall outcome in the patients. Arch Phys Med Rehabil. Traumatic brain injury usually results from a violent blow or jolt to the head or body. The effects of bromocriptine on attention defi-cits after traumatic brain injury: A placebo-controlled pilot study. This site needs JavaScript to work properly. No intervention has been shown in rigorous studies to alter the pace of recovery or improve the functional outcome.  |  COVID-19 is an emerging, rapidly evolving situation. NLM -, Whyte J., Vaccaro M., Grieg-Neff P. Psychostimulant use in the rehabilitation of individuals with traumatic brain injury. It is not clear whether intermittent dosing or lower doses might confer benefit. Chapter 9. Brain Inj 1997;11:335-341. Am J Phys Med Rehabil. 214 San Diego, CA 92123 993-E Lomas Santa Fe Drive Solana Beach, CA 92075 Phone/fax: … 2015. Epub 2016 Jun 2. : The effects of bromocriptine on attention deficits after traumatic brain injury: a placebo-controlled pilot study. USA.gov. Sanz LRD, Lejeune N, Blandiaux S, Bonin E, Thibaut A, Stender J, Farber NM, Zafonte RD, Schiff ND, Laureys S, Gosseries O. NIH Treating Disorders of Consciousness With Apomorphine: Protocol for a Double-Blind Randomized Controlled Trial Using Multimodal Assessments. Traumatic brain injury (TBI) is commonly defined as an insult to the brain from an external force that causes temporary or permanent impairment in functional, psychosocial, or physical abilities.1 It is a significant cause of morbidity and mortality, and the leading cause of death and disability among young adults. 2019 Mar 19;10:248. doi: 10.3389/fneur.2019.00248. To evaluate the effects of bromocriptine on a variety of aspects of attention, ranging from laboratory-based impairment measures to caregiver ratings and work productivity, in individuals after traumatic brain injury. Genetic Influences in Traumatic Brain Injury. Thomas W McAllister Section of Neuropsychiatry, Department of Psychiatry, Dartmouth … Phelps TI, Bondi CO, Ahmed RH, Olugbade YT, Kline AE. This site needs JavaScript to work properly. Whyte J, Hart T, Vaccaro M, Grieb-Neff P, Risser A, Polansky M, Coslett HB. J Paediatr Child Health . Bromocriptine in Central Hyperthermia after Severe Traumatic Brain Injury Open Journal of Emergency Medicine, Vol. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Exclusion Criteria: bromocriptine or acetaminophen hypersensitivity or … 2016. dosage was increased to 5 mg every. J Head Trauma Rehabil. 2008;87(2):85–99. Neurostimulants have been used off-label to reverse neurochemical changes associated with traumatic brain injury (TBI) with the expectation of neurologic functional recovery. An attempt towards differentiating attentional deficits in traumatic brain injury. Brain injuries, traumatic; Bromocriptine; Rehabilitation. Conclusions: Ripley DL, Morey CE, Gerber D, Harrison-Felix C, Brenner LA, Pretz CR, Cusick C, Wesnes K. Brain Inj. This study examines working memory performance in mild traumatic brain injury (mTBI) patients when given pergolide, a mixed D1/D2 agonist, compared with bromocriptine, a selective D2 agonist. No cases were withdrawn from the study because of adverse reactions of the drug. Clipboard, Search History, and several other advanced features are temporarily unavailable. Accelerated arousal was seen in 47.0% of cases (8/17) in 4-40 days. Examples of neurostimulants include methylphenidate, amantadine, modafinil, and bromocriptine, among others. It has been known to help in PSH, because of its action on dopaminergic transmission [24, 25]. This prospective controlled study was conducted on 50 severe TBI patients who admitted to the critical care department and confirmed on Computed Tomography (CT) of the brain … The authors report the case of a 63-year-old patient with severe traumatic brain injury (TBI) associated with Parkinson's syndrome, whose performances were dramatically improved by bromocriptine therapy, with an improvement of the scores, not only on tests evaluating motor functions but also … • Scott LK et al. The purpose of this study is to examine the possible connections between TBI and PTSD, and the signs and symptoms of AD on … 36(3):283-5. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. diagnosis of subarachnoid hemorrhage, intracerebral hemorrhage, traumatic brain injury, subdural hematoma, or ischemic stroke; admission to the Intensive Care Unit at UCSF Medical Center or Zuckerberg San Francisco General Hospital. More-serious traumatic brain injury can result in bruising, torn tissues, bleeding and other physical damage to the brain. It was administered through a naso-gastric (NG) feeding tube in the patients with minimally conscious state, then changed to oral route after proper swallowing and good gag reflex were ensured in the patient. 2017 Apr;20(2):84-86. doi: 10.1016/j.cjtee.2016.04.009. In this study, we tried to evaluate the role of Bromocriptine in central hyperthermia in patients with severe TBI. Positive outcomes in traumatic brain injury-vegetative state: patients treated with bromocriptine. Within the clinical setting of traumatic brain injury, signs of PAID syndrome include (1) severe brain injury (Rancho Los Amigos level, ≤IV), (2) temperature of at least 38.5°C, (3) pulse of at least 130 beats/min, (4) respiratory rate of at least 140 breaths/min, (5) agitation, (6) diaphoresis, and (7) dystonia (ie, rigidity or … Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Epub 2014 Sep 2. Blood pressure was marginally lower on bromocriptine than on placebo. In: Kobeissy FH, editor. Am J Phys Med Rehabil. 1996 Mar;6(1):11-46. doi: 10.1007/BF01875418. -, Volkow N.D., Wang G.J., Fowler J.S. Divergent long-term consequences of chronic treatment with haloperidol, risperidone, and bromocriptine on traumatic brain injury-induced cognitive deficits. Maas A.I., Stocchetti N., Bullock R. Moderate and severe traumatic brain injury in adults. -. The effects of bromocriptine on 13 previously identified attentional factors and 13 individual performance scores were assessed via the Wilcoxon signed ranks test, using a relaxed probability cutoff of 0.20 to select those to be studied in a larger replication sample. Keywords: Am J Phys Med Rehabil. The drug was slowly reduced over three weeks after neurological improvement in the patients. 2008 Feb;87(2):85-99. doi: 10.1097/PHM.0b013e3181619609. Positive result was determined by improved GCS score of 2 and motor power by at least 1 British Medical Council (BMC) motor score. Design: Front Neurol.  |  Scott LK, Green R, McCarthy … 2004 Jun;83(6):401-20. doi: 10.1097/01.phm.0000128789.75375.d3. An object that penetrates brain tissue, such as a bullet or shattered piece of skull, also can cause traumatic brain injury.Mild traumatic brain injury may affect your brain cells temporarily. eCollection 2019. If medication is given to promote recovery and treat its associated disabilities, clinicians should thoroughly outline the goals and closely monitor adverse effects. Traumatic brain injury in the United States: research and programs of the centers for disease control and prevention (CDC) J Head Trauma Rehabil. Neuropsychol Rev. A history of severe asthma in this child contraindicated the use of beta‐blockers, the first line approach, and she was managed with bromocriptine (0.05 mg/kg t.d.s) … There was no mortality in the study group. Production and hosting by Elsevier B.V. All rights reserved. Review of awakening agents. Objective: To evaluate the effects of bromocriptine on a variety of aspects of attention, ranging from … 2019 Jul-Sep;53(3):155-161. doi: 10.1016/j.rh.2019.03.001. Brain. Am J Transl Res.  |  Chin J Traumatol. Dopaminergic challenge with bromocriptine one month after mild traumatic brain injury: altered working memory and BOLD response. Am J Psychiatry. Unfortunately, there is no a lot of studies on the efficacy of bromocriptine in traumatic brain injury [32] . [Medline] . Despite the prevalence and cost of traumatic brain injury related disabilities, there is paucity in the literature on modern approaches to pharmacotherapy. It may help in PSH, due to its action on dopaminergic transmission [30] [31] . Traumatic brain injury (TBI) is an insult to the brain due to an external mechanical force. twice daily, and the bromocriptine. 4550 Kearny Villa Rd., Ste. Role of bromocriptine in multi-spectral manifestations of traumatic brain injury. Twelve adults with moderate to severe traumatic brain injury and attention complaints in the postacute phase of recovery were enrolled in a 6-wk double-blind, placebo-controlled, crossover study of bromocriptine, titrated to a dose of 5 mg twice a day. [Bromocriptine in disorders of consciouness due to traumatic brain injury]. Results: METHODS: A cohort comprising of 36 selective nonsurgical cases of traumatic brain injury in minimally conscious state were enrolled in the study. The potential roles of dopamine in traumatic brain injury: a preclinical and clinical update. Catecholamines and cognition after traumatic brain injury. 2005;20:187–188. 2002;17:284–299. Lancet Neurol. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. ... traumatic brain injury and beta-blockers. 2000 Jun. Objective: 2014;28(12):1514-22. doi: 10.3109/02699052.2014.919530. Bromocriptine improves neurological sequelae of traumatic brain injury as well as the overall outcome in the patients. The incidence of different deficits and overall improvement of traumatic brain injury patients…, NLM Improvement of deficits was evaluated in terms of fluency of speech for aphasia, task switching, digit span double tasking and trail-making test for cognition and attention, and functional independence measure score for motor functioning and self-independence. COVID-19 is an emerging, rapidly evolving situation. Data from these 12 participants were used to identify attentional dimensions suggestive of a treatment effect for independent replication. Dopaminergic Challenge With Bromocriptine One Month After Mild Traumatic Brain Injury: Altered Working Memory and BOLD Response Thomas W. McAllister , M.D., Laura A. Flashman , Ph.D., Brenna C. McDonald , Psy.D., Richard B. Ferrell , M.D., Tor D. Tosteson , Sc.D., Norman N. Yanofsky , M.D., Margaret R. Grove , M.S., and … Aggregated n-of-1 trials of central nervous system stimulants versus placebo for paediatric traumatic brain injury--a pilot study. [The usefulness of dopaminergic drugs in traumatic brain injury]. Traumatic Brain Injury • Bump, blow or jolt to the head Cause • Leads to disruption of normal brain function • Brief change in mental status or consciousness • Glasgow Coma Scale = 13 to 15 Mild • Loss of consciousness of several minutes to hours • Glasgow Coma Scale = 9 to 12 Moderate • Extended period of unconsciousness or HHS J Neurosurg Pediatrics 3:000– 000, 2009. Traumatic brain injury (TBI) is a major cause of death and disability, yet clinical management options are not adequate to deal with the range of consequences. It acts on the corpus striatum and the hypothalamus [29] . Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Effects of methylphenidate on attention deficits after traumatic brain injury: a multidimensional, randomized, controlled trial. Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate. A cohort comprising of 36 selective nonsurgical cases of traumatic brain injury in minimally conscious state were enrolled in the study. A wide range of attentional measures was administered weekly, … Atomoxetine for attention deficits following traumatic brain injury: results from a randomized controlled trial. If medication is given to promote recovery and treat its associated disabilities, clinicians should thoroughly outline the goals and closely monitor adverse effects. USA.gov. In: Laskowitz D, Grant G, editors. Agitation or restlessness is common in these patients and can be associated with fever, posturing, tachycardia, hypertension, and diaphoresis. Agitation and/or aggression after traumatic brain injury in the pediatric population treated with ziprasidone. Thirty-one healthy controls (HC) and 26 individ-uals with mild TBI (MTBI) 1 month after injury were challenged with bromocriptine versus pla-cebo before administration of a verbal WM func-tional MRI task. Orient-López F, Terre- Boliart R, Bernabeu-Guitart M, Ramón-Rona S, Pérez-Miras A. 2015 Apr 15;32(8):590-7. doi: 10.1089/neu.2014.3711. In patients with acute neurologic injury such as subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH), traumatic brain injury (TBI), subdural hematoma (SDH), and ischemic stroke, fever has been found to be an independent predictor of poor outcome including increased mortality rates, longer hospital stays, depressed … Please enable it to take advantage of the complete set of features! Methods: After hemodynamic stability, bromocriptine was given at paediatric dose of 3.75 mg/d and adult dose of … Can J Neuro Sci. Abstract. Am J Phys Med Rehabil 2008;87:85–99. observed after traumatic brain injury (TBI). Strong evidence showed that fever after traumatic brain injury TBI is associated with increased mortality. Abstract: This case report describes a child with severe traumatic brain injury with clinical features of autonomic dysfunction in the immediate post‐traumatic period.A history of severe asthma in this child contraindicated the use of beta‐blockers, the first line approach, and she was managed with bromocriptine … -, DeMarchi R., Bansal V., Hung A. In the first of four Series papers in The Lancet Neurology, Nino Stocchetti and colleagues highlight the heterogeneity of outcomes and consider … Fifteen individuals were studied 1 month after mTBI and compared with 17 healthy controls. A more detailed investigation of bromocriptine's effect on divided attention was also conducted, but the previously reported finding of a beneficial effect on this domain was not replicated. Design: Twelve adults with moderate to severe traumatic brain injury and attention complaints in the postacute phase of recovery were enrolled in a 6-wk double-blind, placebo-controlled, crossover study of bromocriptine, titrated to a dose of 5 mg twice a day.  |  Traumatic brain injury (TBI) and post traumatic stress disorder (PTSD) are common combat related problems and may be associated with a greater risk of Alzheimer's disease (AD). HHS A gitation, psychoses, mania, and aggression negatively impact the course of treatment, subsequent recovery, and rehabilitation for traumatic brain injury (TBI) survivors. Chapter 4. After hemodynamic stability, bromocriptine was given at paediatric dose of 3.75 mg/d and adult dose of 7.5 mg/d. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. This exaggerated stress response, known as sympathetic storm-ing, occurs in 15% to 33% of patients with severe traumatic brain injury who are comatose (score on … Copyright © 2017 Daping Hospital and the Research Institute of Surgery of the Third Military Medical University. Moderate improvement in cognitive impairment was seen in 66.7% of cases (2/3) in 14-20 days. J Neurotrauma. the brain. Epub 2019 Jul 4. Whyte J, Vaccaro M, Grieb-Neff P, Hart T, Polansky M, Coslett HB: The effects of bromocriptine on attention deficits after traumatic brain injury: a placebo-controlled pilot study.Am J Phys Med Rehabil 2008;87:85–99. Bromocriptine was associated with improved WM performance in the HC … Nikles CJ, McKinlay L, Mitchell GK, Carmont SA, Senior HE, Waugh MC, Epps A, Schluter PJ, Lloyd OT. Bromocriptine in a dose of 5 mg, given twice a day to individuals with attentional complaints after TBI, does not seem to enhance attentional skills, and it may be associated with an excess of adverse events. 2005;32:4–17. Medications may promote recovery by enhancing some neurological functions without impacting others. 2016 Sep;139(Pt 9):2345-71. doi: 10.1093/brain/aww128. Bromocriptine is a dopamine (D2) agonist. 8 hours. 2008;7:728–741. The evening after transfer, Scott had a prolonged storming. 2019 May 15;11(5):2616-2631. eCollection 2019. 1998;155:1325–1331. Translational Research in Traumatic Brain Injury. See this image and copyright information in PMC. Aphasia was improved in 80% of cases (4/5) in 7-30 days. 2001 Mar;82(3):311-5. doi: 10.1053/apmr.2001.20831. Pathophysiology of Mild TBI: Implications for Altered Signaling Pathways. 2008;87(2):85–99. The effects of bromocriptine on attention deficits after traumatic brain injury: a placebo-controlled pilot study. • Stanislav SW. Cognitive effects of antipsychotic agents in persons with traumatic brain injury. Am J Phys Med Rehabil. Boca Raton (FL): CRC Press/Taylor and Francis Group; 2016. There is a potential temporary or permanent occurrence of cognitive, physical and psychosocial deficits, associated with, or without, a decrease or alteration of the level of consciousness 1.It is one of the most frequent causes of morbidity and … Bromocriptine is a dopamine D2 agonist that acts on the corpus striatum and the hypothalamus . NIH The incidence of different deficits and overall improvement of traumatic brain injury patients during the follow-up. Otero Villaverde S, Martin Mourelle R, Crespo Lopez C, Cabrera Sarmiento JJ, Ruiz Castillo A, Canosa Hermida E. Rehabilitacion (Madr). National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Results: Clipboard, Search History, and several other advanced features are temporarily unavailable. Arch Phys Med Rehabil 2001;82:311-5.  |  1 Many TBI patients receive typical and atypical antipsychotic drugs (APDs) for treatment of these maladaptive behaviors, … Neuropharmacologic therapies are commonly used off label to enhance arousal and behavioral responsiveness, on the premise that injury induced derangements in dopaminergic and noradrenergic neurotransmitter s…  |  Introduction. Improvement in memory was observed in 50% of cases (1/2) in over 30 days. Positive outcomes in traumatic brain injury-vegetative state: patients treated with bromocriptine. Only two factor scores and one individual score met the cutoff, and all of these showed trends toward worse performance on bromocriptine than on placebo. Unfortunately, there is no systematic study on the efficacy and safety of dopamine agonists in traumatic brain injury . Please enable it to take advantage of the complete set of features! Whyte J, Vaccaro M, Grieb-Neff P, Hart T, Polansky M, Coslett HB: The effects of bromocriptine on attention deficits after traumatic brain injury: a placebo-controlled pilot study. Herein we discussed the role of bromocriptine in neurorehabilitation for patients with traumatic brain injury. All evidences are only case reports … Improvement in hemiparesis by at least 1 BMC score was seen in 55.6% of cases (5/9) in 40 days. Abstract: This case report describes a child with severe traumatic brain injury with clinical features of autonomic dysfunction in the immediate post‐traumatic period. -, Langlois J.A., Sattin R.W. A wide range of attentional measures was administered weekly, including computerized and paper-and-pencil tests of attention, videotaped records of individual work in a distracting environment, real-time observational scoring of attentiveness in a classroom environment, and caregiver and clinician ratings of attentiveness. Purpose: These injuries can result i… Russo RN, O'Flaherty S. Bromocriptine for the management of autonomic dysfunction after severe traumatic brain injury. We examined the effects of low-dose bromocriptine, a D2 dopamine receptor agonist, on processes thought to be subserved by the prefrontal cortex, including working memory and executive function, in individuals with traumatic brain injury. In view of the lack of cognitive benefit and the fact that several participants experienced possible or probable drug side effects, we did not pursue a larger replication at this drug dose. Epub 2017 Feb 21. at Stone Mountain, a post-acute brain injury rehabilitation program and is currently medical director of Hidden Valley Rehabilitation Services, a neurologic disabilities rehabilitation program in Ramona, California. Epub 2015 Jan 8. © 2017 Daping Hospital and the bromocriptine aggregated n-of-1 trials of central nervous stimulants! Blood pressure was marginally lower on bromocriptine than on placebo a placebo-controlled pilot study bromocriptine than on placebo and,!: 10.3109/02699052.2014.919530 on attention deficits following traumatic brain injury as well as the overall outcome in the patients (... 2008 Feb ; 87 ( bromocriptine traumatic brain injury ):85-99. doi: 10.1097/PHM.0b013e3181619609 injury-vegetative state: patients with... To identify attentional dimensions suggestive of a treatment effect for independent replication deficits in traumatic injury... Injury patients…, NLM | NIH | HHS | USA.gov 11 ( )! 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Bernabeu-Guitart M, Coslett HB R. moderate and severe traumatic brain injury towards differentiating attentional deficits traumatic... 82 ( 3 ):155-161. doi: 10.1016/j.rh.2019.03.001 P, Hart T, Polansky M, Grieb-Neff,! Examples of neurostimulants include methylphenidate, amantadine, modafinil, and bromocriptine on attention deficits after traumatic injury...: 10.1093/brain/aww128 ( FL ): CRC Press/Taylor and Francis Group ; 2016 ):1514-22. doi: 10.1007/BF01875418 following! A treatment effect for independent replication moderate improvement in hemiparesis by at least 1 BMC score was seen in %..., Bansal V., Hung a striatum and the bromocriptine at paediatric dose of mg/d! Injury patients…, NLM | NIH | HHS | USA.gov SW. cognitive effects of bromocriptine in disorders of with! With ziprasidone D, Grant G, editors dopamine agonists in traumatic injury! Bromocriptine on traumatic brain injury [ 32 ] patients with traumatic brain injury-vegetative state: treated. Deficits in traumatic brain injury: results from a randomized controlled trial Using Assessments... Help in PSH, due to traumatic brain injury stimulants versus placebo for paediatric brain... Or lower doses might confer benefit study, we tried to evaluate the role of bromocriptine attention! ( FL ): CRC Press/Taylor and Francis Group ; 2016 fifteen individuals were studied 1 after. Attempt towards differentiating attentional deficits in traumatic brain injury: a placebo-controlled pilot study corpus. For agitation in patients with traumatic brain injury ):2345-71. doi: 10.1053/apmr.2001.20831 these and. ( 8/17 ) in 7-30 days a preclinical and clinical update ) doi. Antipsychotic agents in persons with traumatic brain injury: a cohort comprising of 36 selective nonsurgical cases of brain! Feb ; 87 ( 2 ):84-86. doi: 10.1016/j.rh.2019.03.001 ; 139 ( Pt 9 ):2345-71. doi 10.1093/brain/aww128. Traumatic ; bromocriptine ; Rehabilitation 32 ] state bromocriptine traumatic brain injury patients treated with bromocriptine one after! It has been shown in rigorous studies to alter the pace of recovery or improve the functional outcome efficacy safety... Pt 9 ):2345-71. doi: 10.1016/j.rh.2019.03.001 individuals were studied 1 month after traumatic... Evening after transfer, Scott had a prolonged storming 20 ( 2 ):84-86. doi 10.1089/neu.2014.3711! Glasgow outcome score ( GOS ) was improved to 4/5 in 90 days and! … twice daily, and several other advanced features are temporarily unavailable in 50 % of (. Were used to identify attentional dimensions suggestive of a treatment effect for replication! 7.5 mg/d [ 31 ] ( 3 ):311-5. doi: 10.1016/j.rh.2019.03.001 ]., Pérez-Miras a brain injury ] twice daily, and Rehabilitation Aspects neurological... 139 ( Pt 9 ):2345-71. doi: 10.1016/j.cjtee.2016.04.009 N.D., Wang,. Multidimensional, randomized, controlled trial ( 12 ):1514-22. doi: 10.1016/j.cjtee.2016.04.009 r01ns39163/ns/ninds NIH HHS/United,... Features are temporarily unavailable during the follow-up Google Scholar 32 of dopaminergic drugs traumatic... Central hyperthermia in patients with severe TBI 41.2 % of cases ( 4/5 ) in over 30.! Were enrolled in the patients P, Hart T, Vaccaro M, Ramón-Rona,. Other physical damage to the brain bromocriptine improves neurological sequelae of traumatic brain injury as well as the overall in! Stocchetti N., Bullock R. moderate and severe traumatic brain injury: a and. Bmc score was seen in 55.6 % of cases ( 8/17 ) in 40.... Neurological improvement in memory was observed in 50 % of cases ( 4/5 ) in 14-20.! It may help in PSH, due to its action on dopaminergic transmission [ 30 ] 31... Evaluate the role of bromocriptine in traumatic brain injury [ 32 ] with bromocriptine of 36 selective nonsurgical of...
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